姓 名：赵立明
学位学历：博士研究生
职 称：教授
职 务：教研室主任
学科专业：药物化学
E-mail: lmzhao@jsnu.edu.cn
【个人简历】
2008年7月至今，江苏师范大学化院制药教研室
2021年9月-2022年8月，韩国Seoul National University药学院访问学者
2013年10月-2014年10月，美国Purdue University药学院访问学者
2008年6月毕业于上海交通大学药学院，获药物化学专业博士学位
1998年6月毕业于延边大学药学院，获药学专业学士学位；同年7月留校任教，任职于药物化学教研室
【代表性论文】
1. Wang, Tong-Tong; Zhao, Li-Ming.* Synthesis of 2-arylethenesulfonyl fluorides and isoindolinones: Ru-catalyzed C–H activation of nitrones with ethenesulfonyl fluoride. Chemical Communications 2022, 58, 11099-11102.
2. Li, Rui-Li; Fang, Qing-Yun; Li, Mei-Yuan; Wang, Xiang-Shan; Zhao, Li-Ming.* A rearrangement of saccharin-derived cyclic ketimines with 3-chlorooxindoles leading to spiro-1,3-benzothiazine oxindoles. Chemical Communications 2021, 57, 11322-11325.
3. Wang, Yu-Jiao; Wang, Tong-Tong; Liang, Cai-Cai; Li, Zhi-Hao; Zhao, Li-Ming.* Synthesis of Indolo[2,1‑a]benzazepinones through Rhodium-Catalyzed Cascade Reactions of 2‑Arylindoles with Allyl Alcohols. Organic Letters 2021, 23, 6272-6277.
4. Fang, Qing-Yun; Zhao, Li-Ming.* A [4+3] annulation of benzofuran-derived azadienes and α-bromohydroxamates for the synthesis of benzofuran-fused 1,4-diazepinones. Chemical Communications 2020, 56, 14079-14082.
5. Fang, Qing-Yun; Yi, Meng-Hao; Wu, Xiao-Xia; Zhao, Li-Ming.* Regio- and Diastereoselective Spirocyclopropanation of Benzofuran-Derived Azadienes through 1,4-Addition-Induced Dearomatization Reaction under Mild Conditions. Organic Letters 2020, 22, 5266-5270.
6. Fang, Qing-Yun; Jin, Hai-Shan; Wang, Ru-Bing;* Zhao, Li-Ming.* DABCO-mediated [3+3] cycloaddition of azomethine imines with in situ generated nitrile oxides from hydroximoyl chlorides. Chemical Communications 2019, 55, 10587-10590.
7. Zhang, Jie-Huan; Mottamal Madhusoodanan; Jin, Hai-Shan; Guo, Shanchun; Gu, Yan; Wang, Guangdi;* Zhao, Li-Ming.* Design, Synthesis, and Evaluation of Belinostat Analogs as Histone Deacetylase Inhibitors. Future Medicinal Chemistry 2019, 11, 2765-2778.
8. Zhao, Li-Ming;* Zhang, Jie-Huan. Histone Deacetylase Inhibitors in Tumor Immunotherapy. Current Medicinal Chemistry 2019, 26, 2990-3008.
9. Li, De-Feng; Liu, Kun; Jiang, Yi-Xuan; Gu, Yan; Zhang, Jing-Ru; Zhao, Li-Ming.* Access to 3-Prenylated Oxindoles by α-Regioselective Prenylation: Application to the Synthesis of (±)-Debromoflustramine E. Organic Letters 2018, 20, 1122-1125.
10. Zhao, Li-Ming;* Zhang, Ai-Li; Zhang, Jie-Huan; Gao, Hua-Shuai; Zhou, Wei. Zinc-Mediated C-3 α-Prenylation of Isatins with Prenyl Bromide: Access to 3-Prenyl-3-hydroxy-2-oxindoles and Its Application. Journal of Organic Chemistry 2016, 81, 5487-5494.
11. Zhao, Li-Ming; Jin, Hai-Shan; Liu, Jinzhong; Skaar, Todd C.; Ipe, Joseph, Lv, Wei, Flockhart, David A.; Cushman, Mark.* A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β. Bioorganic & Medicinal Chemistry 2016, 24, 5400-5409.
12. Zhao, Li-Ming;* Cao, Feng-Xia; Zhang, Jie-Huan; Szwayab, Jeffrey; Wang, Guangdi.* One-pot synthesis of 1,4-dihydroxy-2-((E)-1-hydroxy-4-phenylbut-3-enyl)anthracene-9,10-diones as novel shikonin analogs and evaluation of their antiproliferative activities. Bioorganic & Medicinal Chemistry Letters 2016, 26, 2691-2694.
13. Zhao, Li-Ming;* Zhang, Ai-Li; Gao, Hua-Shuai; Zhang, Jie-Huan. Synthesis of Furo[3,2-c]benzopyrans via an Intramolecular [4 + 2] Cycloaddition Reaction of o-Quinonemethides. Journal of Organic Chemistry 2015, 80, 10353-10358.
14. Zhao, Li-Ming;* Ma, Feng-Yan; Jin, Hai-Shan; Zheng, Shilong; Zhong, Qiu; Wang, Guangdi.* Design and synthesis of novel hydroxyanthraquinone nitrogen mustard derivatives as potential anticancer agents via a bioisostere approach. European Journal of Medicinal Chemistry 2015, 102, 303-309.
15. Zhao, Li-Ming;* Zhang, Shu-Qing; Dou, Fei; Sun, Rui. Zinc-Mediated Highly α-Regioselective 1,4-Addition of Chalcones with Prenyl Bromide in THF. Organic Letters 2013, 15, 5154-5157.
16. Zhao, Li-Ming;* Zhang, Shu-Qing; Jin, Hai-Shan; Wan, Li-Jing; Dou, Fei. Zinc-Mediated Highly α-Regioselective Prenylation of Imines with Prenyl Bromide. Organic Letters 2012, 14, 886-889.
17. Zhao, Li-Ming;* Zhang, Li-Ming; Liu, Jin-Juan; Wan, Li-Jing; Chen, Yong-Qiang; Zhang, Shu-Qing; Yan, Zhi-Wei; Jiang Ji-Hong. Synthesis and antitumor activity of conjugates of 5-Fluorouracil and emodin. European Journal of Medicinal Chemistry 2012, 47, 255-260.
18. Zhao, Li-Ming;* Jin, Hai-Shan; Wan, Li-Jing; Zhang, Li-Ming. General and Highly α-Regioselective Zinc-Mediated Prenylation of Aldehydes and Ketones. Journal of Organic Chemistry 2011, 76, 1831-1837.
【发明专利】
1. 赵立明，蒋继宏，金海善，刘金娟，张黎明。抗肿瘤活性的大黄素和5-氟尿嘧啶拼合物及其制备方法；201306；ZL201110141407.2
2. 赵立明，马凤燕。具有抗肿瘤活性的羟基蒽醌氮芥衍生物及其制备方法；201511；CN 105037181
3. Cushman, Mark; Lv, Wei; Zhao, Li-Ming. Preparation of triphenylethylene compounds and uses thereof in cancer treatment. 201705, US 20170144975
4. 赵立明，张皆欢，金海善。具有组蛋白去乙酰化酶抑制活性的贝利司他的结构类似物及其应用；201802；CN 107698464
5. 赵立明，刘坤。一种氮杂β-取代Morita-Baylis-Hillman型化合物及其合成方法；202106；ZL201910436982.1
6. 赵立明，刘坤。一种氧代吲哚螺吡啶类化合物及其合成方法；202106；ZL201910436943.1
【会议报告】
1．口头报告，2022 Spring International Convention of The Pharmaceutical Society of Korea, Chungcheongbuk-do C&V Center, Republic of Korea, 2022. 04
2. 口头报告，中国化学会第31届学术年会，杭州，2018. 05
3. 口头报告，第十三届中美华人化学教授会议，南通，2017. 06
4. 口头报告，第九届江淮有机化学论坛，常州，2011. 10
